ATRA-BA Hybrid

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  ATRA-BA hybrid is a mutual prodrug form of all-transretinoic acid and butyric acid .1ATRA-BA hybrid is cleaved to release ATRA and BA in isolated mouse plasma. It inhibits the growth of MDA-MB-231 breast and PC3 prostate cancer cells with GI50values of 0.01 and 1.02 ?M, respectively. ATRA-BA (20 ?M) has 15-fold greater antiproliferative activity in PC3 cells compared to an equimolar concentration of ATRA and BA.

• Smiles:

  O(C(/C=C(/C=C/C=C(/C=C/C=1C(C)(C)CCCC1C)\C)\C)=O)C2=CC=C(COC(CCC)=O)C=C2

• Molecular Formula:

  C31H40O4

• Molecular Weight:

  476.65

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1037543-26-2