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P2Y1 antagonist 4

CAT: 0804-HY-175675Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175675Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration. P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca2+ increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction[1].
UNSPSC
12352100
Target
Keap1-Nrf2; P2Y Receptor
Related Pathways
GPCR/G Protein; NF-κB
Field of Research
Neurological Disease; Cardiovascular Disease
Smiles
O=C1C2=C(C(F)F)N=C(C3=CC=CC(C#N)=C3)N2C=C(C4=CC=C(OC(F)(F)F)C=C4)N1
Molecular Formula
C21H11F5N4O2
Molecular Weight
446.33
References & Citations
[1]Zhang B, et al. Discovery of 1-Difluoromethyl-3- (3-cyanophenyl) -6-[4- (trifluoromethoxy) phenyl]imidazo[1,5-a]pyrazin-8- (7H) -one as a Potent P2Y1 Antagonist for the Treatment of Ischemic Stroke and Myocardial Infarction. J Med Chem. 2025 Aug 28;68 (16) :17990-18015.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y1 Receptor

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