ODM-204

• Description:

  ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme, with IC50s of 80 nM and 22 nM, respectively.

• UNSPSC:

  12352005

• Target:

  Androgen Receptor; Cytochrome P450

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ODM-204.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN([C@H]1C(C)(C)CCC(N2C=CN=C2)=C1)C3=CC(C(F)(F)F)=C(C#N)C=C3

• Molecular Formula:

  C20H21F3N4

• Molecular Weight:

  374.40

• References & Citations:

  [1]Oksala R, et al. Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1. J Steroid Biochem Mol Biol. 2018 Feb 10. pii: S0960-0760 (18) 30078-5.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  CYP17

• CAS Number:

  [1642818-64-1]