ODM-204

CAT: 0804-HY-111421Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-111421Size:1 Each
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Description
ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme, with IC50s of 80 nM and 22 nM, respectively.
CAS Number
[1642818-64-1]
UNSPSC
12352005
Target
Androgen Receptor; Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ODM-204.html
Solubility
10 mM in DMSO
Smiles
CN([C@H]1C(C)(C)CCC(N2C=CN=C2)=C1)C3=CC(C(F)(F)F)=C(C#N)C=C3
Molecular Formula
C20H21F3N4
Molecular Weight
374.40
References & Citations
[1]Oksala R, et al. Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1. J Steroid Biochem Mol Biol. 2018 Feb 10. pii: S0960-0760 (18) 30078-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CYP17

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