ODM-203

CAT: 0804-HY-119367-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119367-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ODM-203 is an orally active and selective FGFR/VEGFR inhibitor with IC50 values of 6, 11, 16, 5, 9, 26 and 35 nM for FGFR3/1/2 and VEGFR3/2/1/4, respectively. ODM-203 has strong anti-tumour activity and activates immune responses in the tumour microenvironment[1].
CAS Number
[1430723-35-5]
Product Name Alternative
Saponin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/odm-203.html
Purity
99.62
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
CN(N=C1)C=C1C2=CC=C3C(N=CN3C4=CC(C5=CC=C(F)C=C5F)=CC(NS(C6CC6)(=O)=O)=C4)=C2
Molecular Formula
C26H21F2N5O2S
Molecular Weight
505.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Holmström TH, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019 Jan;18 (1) :28-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

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