ODM-203

• Description:

  ODM-203 is an orally active and selective FGFR/VEGFR inhibitor with IC50 values of 6, 11, 16, 5, 9, 26 and 35 nM for FGFR3/1/2 and VEGFR3/2/1/4, respectively. ODM-203 has strong anti-tumour activity and activates immune responses in the tumour microenvironment[1].

• Product Name Alternative:

  Saponin

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  FGFR; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/odm-203.html

• Purity:

  99.62

• Solubility:

  DMSO : 66.67 mg/mL (ultrasonic)

• Smiles:

  CN(N=C1)C=C1C2=CC=C3C(N=CN3C4=CC(C5=CC=C(F)C=C5F)=CC(NS(C6CC6)(=O)=O)=C4)=C2

• Molecular Formula:

  C26H21F2N5O2S

• Molecular Weight:

  505.54

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Holmström TH, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019 Jan;18 (1) :28-38.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

• CAS Number:

  [1430723-35-5]