(±) -PPCC (oxalate)

• Description:

  (±) -PPCC oxalate is a sigma-1 agonist that mainly interacts with sigma-1 receptors with Ki of 1.5 nM. (±) -PPCC oxalate has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats[1].

• UNSPSC:

  12352005

• Target:

  Sigma Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/racemic-ppcc-oxalate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C(O)=O)=O.COC([C@]1(C2=CC=C(C=C2)C)[C@@H](C1)CN3CCC(CC3)(C4=CC=CC=C4)O)=O

• Molecular Formula:

  C26H31NO7

• Molecular Weight:

  469.53

• References & Citations:

  [1]Antonini V, et al. Anti-amnesic properties of (+/-) -PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J Neurochem. 2009 May;109 (3) :744-54.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1781628-91-8]