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Bleximenib (oxalate)

CAT: 0804-HY-148669A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148669A-01Size:1 mg
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Description
Bleximenib (JNJ-75276617) oxalate is an orally active and selective menin-KMT2A inhibitor, with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib oxalate can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib oxalate can be used in the research of tumors such as leukemia[1][2].
CAS Number
2866179-95-3
Product Name Alternative
JNJ-75276617 (oxalate) ; Menin-MLL inhibitor 24 (oxalate)
UNSPSC
12352005
Target
Apoptosis; FLT3; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bleximenib-oxalate.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C(O)=O.COCCN(C)CCC[C@@H](N1CC2(C1)CN(C3=NC=NN=C3OC4=C(C=C(C=C4)F)C(N(CC)C(C)C)=O)CC2)C(C)C
Molecular Formula
C34H52FN7O7
Molecular Weight
689.82
References & Citations
[1]Hogeling SM, et al. Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia. Haematologica. 2024 Dec 19.|[2]Kwon MC, et al. Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias. Blood. 2024 Sep 12;144 (11) :1206-1220.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Chemical Information

Bleximenib oxalate
CAS Number2866179-95-3
PubChem CID171034104
IUPAC NameN-ethyl-5-fluoro-2-[[5-[2-[(3R)-6-[2-methoxyethyl(methyl)amino]-2-methylhexan-3-yl]-2,7-diazaspiro[3.4]octan-7-yl]-1,2,4-triazin-6-yl]oxy]-N-propan-2-ylbenzamide;oxalic acid
Molecular FormulaC34H52FN7O7
Molecular Weight689.8
Topological Polar Surface Area162
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count14
Rotatable Bond Count16
Heavy Atom Count49
Formal Charge0
Complexity932
SMILES
CCN(C(C)C)C(=O)C1=C(C=CC(=C1)F)OC2=C(N=CN=N2)N3CCC4(C3)CN(C4)[C@H](CCCN(C)CCOC)C(C)C.C(=O)(C(=O)O)O
InChI
InChI=1S/C32H50FN7O3.C2H2O4/c1-8-40(24(4)5)31(41)26-18-25(33)11-12-28(26)43-30-29(34-22-35-36-30)38-15-13-32(19-38)20-39(21-32)27(23(2)3)10-9-14-37(6)16-17-42-7;3-1(4)2(5)6/h11-12,18,22-24,27H,8-10,13-17,19-21H2,1-7H3;(H,3,4)(H,5,6)/t27-;/m1./s1
InChIKey
OYKHOVACUSUKFI-HZPIKELBSA-N
Chemical Structure
2D Structure
2D structure of Bleximenib oxalate
CAS: 2866179-95-3
CID: 171034104
Formula: C34H52FN7O7
MW: 689.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight689.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count14
Rotatable Bond Count16
Exact Mass689.39122519
Monoisotopic Mass689.39122519
Topological Polar Surface Area162 Ų
Heavy Atom Count49
Formal Charge0
Complexity932
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS5819820Bleximenib oxalate
A24334-50Bleximenib oxalate (JNJ-75276617 oxalate) 50mg
A24334-5Bleximenib oxalate (JNJ-75276617 oxalate) 5mg
A24334-1Bleximenib oxalate (JNJ-75276617 oxalate) 1mg
A24334-10Bleximenib oxalate (JNJ-75276617 oxalate) 10mg
GTR19277529-01Bleximenib
GTR19274481-01(S) -Bleximenib
A24337-100Bleximenib (JNJ-75276617) 100mg
A24337-10Bleximenib (JNJ-75276617) 10mg
A24337-50Bleximenib (JNJ-75276617) 50mg

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