(±)-PPCC (hemioxalate)

• UNSPSC Description:

  (±)-PPCC hemioxalate is a compound that has the ability to regulate the activity of the sigma-1 receptor. (±)-PPCC hemioxalate can selectively bind sigma-1 protein (s1), and then activate s1 receptor leading to dissociation of s1-BIP complex to regulate ER-mitochondrial calcium signaling, which plays an important role in cell bioenergy and cell survival. (±)-PPCC hemioxalate can be used to study sigma-1 receptors in cocaine addiction, forgetting, pain, depression, Alzheimer's disease, stroke, and cancer[1].

• Target Antigen:

  Sigma Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/racemic-ppcc-hemioxalate.html

• Smiles:

  O=C([C@@]1(C2=CC=C(C)C=C2)[C@@H](CN3CCC(C4=CC=CC=C4)(O)CC3)C1)OC.O=C(O)C(O)=O.[0.5]

• Molecular Weight:

  424.23

• References & Citations:

  [1]Sarpietro M G, et al. DSC investigation of the effect of the new sigma ligand PPCC on DMPC lipid membrane[J]. International Journal of Pharmaceutics, 2014, 469(1): 88-93.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  932736-91-9