(±) -PPCC (hemioxalate)

• Description :

  (±) -PPCC hemioxalate is a compound that has the ability to regulate the activity of the sigma-1 receptor. (±) -PPCC hemioxalate can selectively bind sigma-1 protein (s1), and then activate s1 receptor leading to dissociation of s1-BIP complex to regulate ER-mitochondrial calcium signaling, which plays an important role in cell bioenergy and cell survival. (±) -PPCC hemioxalate can be used to study sigma-1 receptors in cocaine addiction, forgetting, pain, depression, Alzheimer's disease, stroke, and cancer[1].

• UNSPSC :

  12352005

• Target :

  Sigma Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/racemic-ppcc-hemioxalate.html

• Smiles :

  O=C([C@@]1(C2=CC=C(C)C=C2)[C@@H](CN3CCC(C4=CC=CC=C4)(O)CC3)C1)OC.O=C(O)C(O)=O.[0.5]

• Molecular Formula :

  C24H29NO3.0.5C2H2O4

• Molecular Weight :

  424.23

• References & Citations :

  [1]Sarpietro M G, et al. DSC investigation of the effect of the new sigma ligand PPCC on DMPC lipid membrane[J]. International Journal of Pharmaceutics, 2014, 469 (1) : 88-93.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [932736-91-9]