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PTAC (oxalate)

CAT: 0804-HY-107656Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107656Size:1 Each
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Description
PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells) . PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects[1][2].
CAS Number
201939-40-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ptac-oxalate.html
Solubility
10 mM in DMSO
Smiles
CCCSC1=NSN=C1[C@@H]2[C@@H]3C[N@@](CCC3)C2.OC(C(O)=O)=O
Molecular Formula
C14H21N3O4S2
Molecular Weight
359.46
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]F P Bymaster, et al. Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R) 6- (3-propylthio-1,2,5-thiadiazol-4-yl) -1-azabicyclo[3.2.1]octane. Eur J Pharmacol. 1998 Sep 4;356 (2-3) :109-19.|[2] (5R,6R) 6- (3-Propylthio-1,2,5-thiadiazol-4-yl) -1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg. 2017 Apr;124 (4) :1330-1338.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1; mAChR2; mAChR3; mAChR4; mAChR5

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