AZD 2066 (hydrate)

CAT: 0804-HY-110255ASize: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-110255ASize:5 mg
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Description
AZD-2066 hydrate is a selective, orally active and blood-brain barrier-permeating mGluR5 antagonist. AZD 2066 hydrate activates the BDNF/trkB signaling pathway. AZD 2066 hydrate can be used in the research of neuropathic pain, major depressive disorder and gastroesophageal reflux disease[1][2][3][5].
UNSPSC
12352005
Target
Calcium Channel; mGluR; Trk Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/azd-2066-hydrate.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CN1C(C2=CC=NC=C2)=NN=C1O[C@@H](C3=NOC(C4=CC(Cl)=CC=C4)=C3)C.O.[1/4]
Molecular Formula
C19H16ClN5O2.1/4H2O
Molecular Weight
386.33
References & Citations
[1]Kågedal M, et al. A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066-estimating occupancy in the absence of a reference region. Neuroimage. 2013 Nov 15;82:160-9.|[2]Swedberg MD, et al. AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J Pharmacol Exp Ther. 2014 Aug;350 (2) :212-22.|[3]Antoniu SA. Discontinued drugs for pulmonary, allergy, gastrointestinal, arthritis (2012) . Expert Opin Investig Drugs. 2013 Nov;22 (11) :1453-64.|[4]Jong YI, et al. Location and Cell-Type-Specific Bias of Metabotropic Glutamate Receptor, mGlu5, Negative Allosteric Modulators. ACS Chem Neurosci. 2019 Nov 20;10 (11) :4558-4570.|[5]Jiang X, et al. mGluR5 Facilitates Long-Term Synaptic Depression in a Stress-Induced Depressive Mouse Model. Can J Psychiatry. 2020 May;65 (5) :347-355.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MGluR5

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