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MRS5698

CAT: 0804-HY-110202Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-110202Size:1 Each
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Description
MRS5698 is a selective Gi protein-coupled A3 adenosine receptor (A3AR) agonist, with Kis of approximately 3 nM for human and mouse A3AR, respectively. MRS5698 can be used for the research of pain and psoriasis[1][2].
CAS Number
[1377273-00-1]
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mrs5698.html
Solubility
10 mM in DMSO
Smiles
CNC([C@]12[C@]([C@](N3C4=NC(C#CC5=CC(F)=C(C=C5)F)=NC(NCC6=CC(Cl)=CC=C6)=C4N=C3)([H])[C@@H]([C@@H]2O)O)([H])C1)=O
Molecular Formula
C28H23ClF2N6O3
Molecular Weight
564.97
References & Citations
[1]Tosh DK, et al. Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 2015;11 (3) :371-387.|[2]Wahlman C, et al. Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms. Pain. 2018;159 (6) :1025-1034.|[3]López-Cano M, et al. Optical control of adenosine A3 receptor function in psoriasis. Pharmacol Res. 2021 Aug;170:105731.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A3 receptor (A3R)

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