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MRS2693 (ammonium)

CAT: 0804-HY-117356ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117356ASize:1 Each
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Description
MRS2693 ammonium is the ammonium dalt form of MRS2693. MRS2693 ammonium is a selective agonist for P2Y6 with an EC50 of 0.015 μM. MRS2693 ammonium protects C2C12 skeletal muscle cells from TNFα-induced apoptosis. MRS2693 ammonium reduces the activation of NF-kB, activates the ERK1/2 pathway, and has a cytoprotective effect on mouse ischemia-reperfusion injury model[1][2].
CAS Number
911391-37-2
UNSPSC
12352005
Target
Apoptosis; ERK; NF-κB; P2Y Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mrs2693-ammonium.html
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1COP(O)(OP(O)(O)=O)=O.N.N.N
Molecular Formula
C9H22IN5O12P2
Molecular Weight
581.15
References & Citations
[1]Mamedova LK, et al., Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol Res. 2008 Sep-Oct;58 (3-4) :232-9. |[2]Girard M, et al., Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6 receptor. Biochim Biophys Acta Mol Cell Res. 2023 Jun;1870 (5) :119476.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y6 Receptor

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