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MRS5663

CAT: 0804-HY-161717Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161717Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRS5663 (Compound 3a) is an A3AR agonist, with an EC50 of 5.62 nM for β-arrestin2 recruitment assay. MRS5663 has a cytoprotective effect on skeletal muscle ischemia-reperfusion injury/claudication model[1].
CAS Number
1377272-66-6
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mrs5663.html
Smiles
CNC1=NC(C#CC2=CC=CC=C2Cl)=NC3=C1N=CN3[C@@H]4[C@@H](C5)[C@]5(C(NC)=O)[C@@H](O)[C@H]4O
Molecular Formula
C22H21ClN6O3
Molecular Weight
452.89
References & Citations
[1]Tosh D K, et al. 2-Substituted (N) -Methanocarba A3 Adenosine Receptor Agonists: In Silico, In Vitro, and In Vivo Characterization. ACS Pharmacology & Translational Science, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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