PQ-10

• UNSPSC Description:

  PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 andED50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia[1].

• Target Antigen:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pq-10.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  COC1=CC(C(N(CC2)C[C@@H]2OC3=NC(C=CC=C4)=C4N=C3)=NC=N5)=C5C=C1OC

• Molecular Weight:

  403.43

• References & Citations:

  [1]Dedeurwaerdere S, et al. Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: a potential translational biomarker. J Pharmacol Exp Ther. 2011;339(1):210-217.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  927691-21-2