PQ-1

CAT: 0804-HY-14584Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-14584Size:1 Each
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Description
PQ-1 is a gap junction enhancer. PQ-1 activates p44/42 MAPK, increases phosphorylated p38-MAPK, reduces Bcl-2 expression, increases the cleavage of pro-caspase-3. PQ-1 affects the Raf-MEK-ERK cascade, induces Apoptosis. PQ-1 can be used in the research of breast cancer[1].
CAS Number
[955995-48-9]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; ERK; MEK; p38 MAPK; Raf
Related Pathways
Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer
Smiles
NCCCNC1=C2C(C(C)=CC=N2)=C(OC3=CC=CC(C(F)(F)F)=C3)C(OC)=C1
Molecular Formula
C21H22F3N3O2
Molecular Weight
405.41
References & Citations
[1]Shishido SN, et al. Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells. Int J Mol Sci. 2016 Jan 29;17 (2) :178.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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