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NBI 35965 (hydrochloride)

CAT: 0804-HY-110056-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110056-01Size:5 mg
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Description
NBI 35965 hydrochloride is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 hydrochloride does not inhibit CRF2. NBI 35965 hydrochloride reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride shows anxiolytic effects[1][2].
CAS Number
1782228-59-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
CRFR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nbi-35965-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CC[C@H]1CN2N=C(C3=C(C=C(C=C3)Cl)Cl)C4=NC(C)=CC(N1CC5CC5)=C42.Cl
Molecular Formula
C21H23Cl3N4
Molecular Weight
437.79
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Gross RS, et al. Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists. J Med Chem. 2005 Sep 8;48 (18) :5780-93.|[2]Mulugeta Million, et al. A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res. 2003 Sep 19;985 (1) :32-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CRFR1

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