Ro 0437626

• Description :

  Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM) [1].

• UNSPSC :

  12352005

• Target :

  P2X Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ro-0437626.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=NC2=CC=CC=C2N1)N[C@H](CC3=CSC=N3)C(N[C@@H](CC4CCCCC4)[C@@H](O)[C@H](C5CC5)O)=O

• Molecular Formula :

  C27H35N5O4S

• Molecular Weight :

  525.66

• References & Citations :

  [1]Jaime-Figueroa S, et al. Discovery and synthesis of a novel and selective drug-like P2X (1) antagonist. Bioorg Med Chem Lett. 2005;15 (13) :3292-3295.|[2]Harper MT, et al. Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P (2X1) receptors, not a novel non-capacitative Ca2+ entry. J Thromb Haemost. 2010;8 (7) :1604-1613.|[3]King BF, et al. Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br J Pharmacol. 2004;142 (3) :519-530.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  P2X1 Receptor

• CAS Number :

  [134362-79-1]