Ro 0437626

• Description:

  Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM) [1].

• UNSPSC:

  12352005

• Target:

  P2X Receptor

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ro-0437626.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=NC2=CC=CC=C2N1)N[C@H](CC3=CSC=N3)C(N[C@@H](CC4CCCCC4)[C@@H](O)[C@H](C5CC5)O)=O

• Molecular Formula:

  C27H35N5O4S

• Molecular Weight:

  525.66

• References & Citations:

  [1]Jaime-Figueroa S, et al. Discovery and synthesis of a novel and selective drug-like P2X (1) antagonist. Bioorg Med Chem Lett. 2005;15 (13) :3292-3295.|[2]Harper MT, et al. Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P (2X1) receptors, not a novel non-capacitative Ca2+ entry. J Thromb Haemost. 2010;8 (7) :1604-1613.|[3]King BF, et al. Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br J Pharmacol. 2004;142 (3) :519-530.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  P2X1 Receptor

• CAS Number:

  [134362-79-1]