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SC 51089

CAT: 0804-HY-108563Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-108563Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SC 51089 is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 exhibits neuroprotective activity[1][2][3].
CAS Number
[146033-02-5]
UNSPSC
12352005
Hazard Statement
H301-H315-H319-H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sc-51089.html
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(N1C2=CC(Cl)=CC=C2OC3=CC=CC=C3C1)NNC(CCC4=CC=NC=C4)=O.[H]Cl
Molecular Formula
C22H20Cl2N4O3
Molecular Weight
459.33
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Abramovitz M, et, al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483 (2) :285-93. |[2]Saleem S, et, al. Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. J Neurosci Res. 2007 Aug 15;85 (11) :2433-40. |[3]Anglada-Huguet M, et, al. Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease. Mol Neurobiol. 2014 Apr;49 (2) :784-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP; FP; TXA2/TP

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