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JNJ-5207787

CAT: 0804-HY-107732Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107732Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50s of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors[1].
CAS Number
683746-68-1
UNSPSC
12352005
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-5207787.html
Purity
98.00
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
N#CC1=CC=CC(/C=C/C(N(C2CCN(CCC3CCCC3)CC2)C4=CC=C(CCN5C(C)=O)C5=C4)=O)=C1
Molecular Formula
C32H38N4O2
Molecular Weight
510.67
References & Citations
[1]Bonaventure P, et al. Characterization of N- (1-Acetyl-2,3-dihydro-1H-indol-6-yl) -3- (3-cyano-phenyl) -N-[1- (2-cyclopentyl-ethyl) -piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide YY2 receptor. J Pharmacol Exp Ther. 2004 Mar;308 (3) :1130-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NPY Y2 receptor

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