JNJ-5207787

• Description:

  JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50s of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors[1].

• UNSPSC:

  12352005

• Target:

  Neuropeptide Y Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/jnj-5207787.html

• Purity:

  98.00

• Solubility:

  DMSO : 5 mg/mL (ultrasonic; warming)

• Smiles:

  N#CC1=CC=CC(/C=C/C(N(C2CCN(CCC3CCCC3)CC2)C4=CC=C(CCN5C(C)=O)C5=C4)=O)=C1

• Molecular Formula:

  C32H38N4O2

• Molecular Weight:

  510.67

• References & Citations:

  [1]Bonaventure P, et al. Characterization of N- (1-Acetyl-2,3-dihydro-1H-indol-6-yl) -3- (3-cyano-phenyl) -N-[1- (2-cyclopentyl-ethyl) -piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide YY2 receptor. J Pharmacol Exp Ther. 2004 Mar;308 (3) :1130-7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NPY Y2 receptor

• CAS Number:

  [683746-68-1]