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JNJ-27141491

CAT: 0804-HY-110132-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110132-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNJ-27141491 is a selective, noncompetitive and orally active functional antagonist of human CCR2[1].
CAS Number
871313-59-6
UNSPSC
12352005
Hazard Statement
H315, H319
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnj-27141491.html
Purity
97.01
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC[C@@H](C1=CC(F)=C(F)C=C1)N2C(C(OC)=O)=C(C3=CC=NO3)NC2=S
Molecular Formula
C17H15F2N3O3S
Molecular Weight
379.38
Precautions
H315, H319
References & Citations
[1]Buntinx M, et al. Pharmacological profile of JNJ-27141491 [ (S) -3-[3,4-difluorophenyl) -propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2. J Pharmacol Exp Ther. 2008 Oct;327 (1) :1-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR2

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