JNJ-5207852

• UNSPSC Description:

  JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.

• Target Antigen:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling

• Field of Research:

  Neurological Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/JNJ-5207852.html

• Purity:

  98.0

• Solubility:

  DMSO : 77.5 mg/mL (ultrasonic)

• Smiles:

  N1(CCCOC2=CC=C(CN3CCCCC3)C=C2)CCCCC1

• Molecular Weight:

  316.48

• References & Citations:

  [1]Barbier AJ, et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.|[2]Abuhamdah RM, et al. Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze. Front Syst Neurosci. 2012 Jul 16;6:54.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  398473-34-2