ONO-4817

• Description :

  ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP) . Inhibition of matrix metalloproteinases (MMPs) is expected to suppress atherosclerotic neointimal proliferation and thus limits atheromatous plaque progression. ONO-4817 suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit[1].

• UNSPSC :

  12352005

• Target :

  MMP

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ono-4817.html

• Purity :

  98.94

• Solubility :

  DMSO : 125 mg/mL (ultrasonic) |Ethanol : 15 mg/mL (ultrasonic)

• Smiles :

  ONC([C@@H](C)C[C@@H](COCOCC)NC(C(C=C1)=CC=C1OC2=CC=CC=C2)=O)=O

• Molecular Formula :

  C22H28N2O6

• Molecular Weight :

  416.47

• References & Citations :

  [1]Okamoto Y, et al. A matrix metalloproteinase inhibitor, ONO-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. Int Heart J. 2007;48 (3) :369-378.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [223472-31-9]