T-98475

• Description :

  T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM[1].

• UNSPSC :

  12352005

• Target :

  GnRH Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/t-98475.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CN(CC2=C(F)C=CC=C2F)C3=C(C1=O)C(CN(CC4=CC=CC=C4)C)=C(C5=CC=C(NC(C(C)C)=O)C=C5)S3)OC(C)C

• Molecular Formula :

  C37H37F2N3O4S

• Molecular Weight :

  657.77

• References & Citations :

  [1]Imada T, et al. Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists. J Med Chem. 2006 Jun 29;49 (13) :3809-25.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [199119-18-1]