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(RS) -PPG

CAT: 0804-HY-107514Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107514Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(RS) -PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].
CAS Number
120667-15-4
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rs-ppg.html
Purity
99.76
Solubility
H2O : 2.86 mg/mL (ultrasonic; warming; adjust pH to 12 with 0.5 M NaOH; heat to 60°C)
Smiles
O=C(O)C(N)C1=CC=C(P(O)(O)=O)C=C1
Molecular Formula
C8H10NO5P
Molecular Weight
231.14
References & Citations
[1]Gasparini F, et al. (R, S) -4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J Pharmacol Exp Ther. 1999 Jun;289 (3) :1678-87.|[2]Zhao L, et al. Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons. Neurotox Res. 2009 Aug;16 (2) :174-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4; mGluR6; mGluR7; mGluR8

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