(RS) -PPG

• Description :

  (RS) -PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].

• UNSPSC :

  12352005

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/rs-ppg.html

• Purity :

  99.76

• Solubility :

  H2O : 2.86 mg/mL (ultrasonic; warming; adjust pH to 12 with 0.5 M NaOH; heat to 60°C)

• Smiles :

  O=C(O)C(N)C1=CC=C(P(O)(O)=O)C=C1

• Molecular Formula :

  C8H10NO5P

• Molecular Weight :

  231.14

• References & Citations :

  [1]Gasparini F, et al. (R, S) -4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J Pharmacol Exp Ther. 1999 Jun;289 (3) :1678-87.|[2]Zhao L, et al. Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons. Neurotox Res. 2009 Aug;16 (2) :174-83.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR4; mGluR6; mGluR7; mGluR8

• CAS Number :

  [120667-15-4]