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Ro 67-4853

CAT: 0804-HY-107506Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107506Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor) . Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation[1][2][3][4].
CAS Number
302841-89-0
UNSPSC
12352005
Hazard Statement
H302, H361, H372, H410
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro-67-4853.html
Purity
99.90
Solubility
DMF : 16 mg/mL (ultrasonic; warming)
Smiles
CCCCOC(NC(C1C2=CC=CC=C2OC3=CC=CC=C13)=O)=O
Molecular Formula
C19H19NO4
Molecular Weight
325.36
Precautions
H302, H361, H372, H410
References & Citations
[1]Knoflach F, et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site [published correction appears in Proc Natl Acad Sci U S A 2001 Dec 18;98 (26) :15393]. Proc Natl Acad Sci U S A. 2001;98 (23) :13402-13407. |[2]Jiang JY, et al. Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α. J Biol Chem. 2014;289 (3) :1649-1661.|[3]Salt TE, et al. Potentiation of sensory responses in ventrobasal thalamus in vivo via selective modulation of mGlu1 receptors with a positive allosteric modulator. Neuropharmacology. 2012;62 (4) :1695-1699. |[4]Sheffler DJ, et al. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology. 2008;55 (4) :419-427.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1

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