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SCH-42354

CAT: 0804-HY-106975Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106975Size:1 Each
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Description
SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP) . SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2].
CAS Number
144505-58-8
UNSPSC
12352005
Target
Neprilysin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sch-42354.html
Solubility
10 mM in DMSO
Smiles
CSCC[C@@H](C(O)=O)NC([C@@H](CS)CC1=C(C=CC=C1)C)=O
Molecular Formula
C16H23NO3S2
Molecular Weight
341.49
References & Citations
[1]Thompson JS, et, al. Neutral endopeptidase inhibition increases the potency of ANP in isolated rat pulmonary resistance vessels and isolated blood perfused lungs. Pulm Pharmacol. 1995 Apr-Jun;8 (2-3) :143-7.|[2]Watkins RW, et, al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6 (5 Pt 1) :357-68.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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