SCH 50911

• Description:

  SCH 50911, (+) - (S) -5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA (B) receptor antagonist, binds to GABA (B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA (B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].

• UNSPSC:

  12352005

• Target:

  GABA Receptor

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/sch-50911.html

• Purity:

  98.0

• Solubility:

  H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (O) C[C@H]1CNC (C) (C) CO1

• Molecular Formula:

  C8H15NO3

• Molecular Weight:

  173.21

• References & Citations:

  [1]Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA (B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362 (1) :35-41.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  733717-87-8