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SCH 50911

CAT: 0804-HY-12783A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12783A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SCH 50911, (+) - (S) -5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA (B) receptor antagonist, binds to GABA (B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA (B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].
CAS Number
733717-87-8
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sch-50911.html
Purity
98.0
Solubility
H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C[C@H]1CNC(C)(C)CO1
Molecular Formula
C8H15NO3
Molecular Weight
173.21
References & Citations
[1]Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA (B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362 (1) :35-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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