SCH 50911

• Description :

  SCH 50911, (+) - (S) -5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA (B) receptor antagonist, binds to GABA (B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA (B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].

• UNSPSC :

  12352005

• Target :

  GABA Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sch-50911.html

• Purity :

  98.0

• Solubility :

  H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(O)C[C@H]1CNC(C)(C)CO1

• Molecular Formula :

  C8H15NO3

• Molecular Weight :

  173.21

• References & Citations :

  [1]Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA (B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362 (1) :35-41.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [733717-87-8]