SCH-39370

• Description :

  SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney with an IC50 value of 11.2 nM. SCH-39370 potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats[1].

• UNSPSC :

  12352005

• Target :

  Neprilysin; Prolyl Endopeptidase (PREP)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/sch-39370.html

• Smiles :

  OC([C@H](CCC1=CC=CC=C1)N[C@H](C(NC[C@H](O)C(O)=O)=O)CC2=CC=CC=C2)=O

• Molecular Formula :

  C22H26N2O6

• Molecular Weight :

  414.45

• References & Citations :

  [1]Sybertz EJ, et al. SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats. J Pharmacol Exp Ther. 1989 Aug;250 (2) :624-31.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [115406-23-0]