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SCH-39370

CAT: 0804-HY-139803Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139803Size:1 Each
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Description
SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney with an IC50 value of 11.2 nM. SCH-39370 potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats[1].
CAS Number
115406-23-0
UNSPSC
12352005
Target
Neprilysin; Prolyl Endopeptidase (PREP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sch-39370.html
Smiles
OC([C@H](CCC1=CC=CC=C1)N[C@H](C(NC[C@H](O)C(O)=O)=O)CC2=CC=CC=C2)=O
Molecular Formula
C22H26N2O6
Molecular Weight
414.45
References & Citations
[1]Sybertz EJ, et al. SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats. J Pharmacol Exp Ther. 1989 Aug;250 (2) :624-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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