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SCH-42354

CAT: 0931-T61095-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61095-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
144505-58-8
Target
Neprilysin, Others
Related Pathways
Others, Metabolism
Bioactivity
SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP), serving as the active form of the prodrug SCH-42495. By inhibiting NEP hydrolysis, SCH-42354 enhances the activity of atrial natriuretic peptide (ANP) and prevents the hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. Furthermore, SCH-42354 exhibits antihypertensive activity [1] [2].
Smiles
C([C@@H](C(N[C@@H](CCSC)C(O)=O)=O)CS)C1=C(C)C=CC=C1
Molecular Formula
C16H23NO3S2
Molecular Weight
341.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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