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(Z) -GW 5074

CAT: 0804-HY-10542ASize: 1 EachDry Ice: NoHazardous: No
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Description
(Z) -GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z) -GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder[1].
CAS Number
1233748-60-1
UNSPSC
12352005
Target
Atg8/LC3; Raf
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/z-gw-5074.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=C(I)C=C2)/C1=C/C3=CC(Br)=C(O)C(Br)=C3.[Z]
Molecular Formula
C15H8Br2INO2
Molecular Weight
520.94
References & Citations
[1]Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
C-Raf

Chemical Information

GW-5074

GW5074 is a potent and selective c-Raf inhibitor.

CAS Number1233748-60-1
PubChem CID5924208
IUPAC Name(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
Molecular FormulaC15H8Br2INO2
Molecular Weight520.94
XLogP4.6
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity447
SMILES
C1=CC2=C(C=C1I)/C(=C/C3=CC(=C(C(=C3)Br)O)Br)/C(=O)N2
InChI
InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChIKey
LMXYVLFTZRPNRV-KMKOMSMNSA-N
Chemical Structure
2D Structure
2D structure of GW-5074
CAS: 1233748-60-1
CID: 5924208
Formula: C15H8Br2INO2
MW: 520.94
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight520.94
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass520.79460
Monoisotopic Mass518.79665
Topological Polar Surface Area49.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity447
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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