GW 796406

• Description:

  GW 796406 is a novel vascular peptidase inhibitor. GW 796406’s inhibitory activity against NEP (IC50 ≈ 1.1-2.5 nM) is about three times that of ACE (IC50 ≈ 1.6-4.7 nM) . GW 796406 can be used for research on cardiovascular conditions[1].

• UNSPSC:

  12352005

• Target:

  Angiotensin-converting Enzyme (ACE) ; Neprilysin

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cardiovascular Disease

• Smiles:

  CC (C) [C@H] (CS) C (N[C@H] (C (O) =O) CC1=CC=C (N2C=CC=N2) C=C1) =O

• Molecular Formula:

  C18H23N3O3S

• Molecular Weight:

  361.46

• References & Citations:

  [1]Sulpizio AC, et al. Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315 (3) :1306-13.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  581096-47-1