Products for Research Use Only
RegisterLogin

PD 168568

CAT: 0804-HY-103407Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-103407Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PD 168568 is a orally active and potent dopamine receptor D4 (DRD4) antagonist. PD 168568 contains an isoindolinone and is selective for the D4 receptor versus D2 and D3, with Ki values of 8.8, 1842, and 2682 nM, respectively. PD 168568 can be used for glioblastoma (GBM) research[1][2].
CAS Number
210688-56-5
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pd-168568.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(CCN2CCN(C3=CC=C(C)C(C)=C3)CC2)C4=C1C=CC=C4
Molecular Formula
C22H27N3O
Molecular Weight
349.47
References & Citations
[1]Dolma S, et al. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016 Jun 13;29 (6) :859-873.|[2]Lindsley CW, et al. Return of D4 Dopamine Receptor Antagonists in Drug Discovery. J Med Chem. 2017 Sep 14;60 (17) :7233-7243.|[3]Belliotti TR, et al. Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg Med Chem Lett. 1998 Jun 16;8 (12) :1499-502.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor; D3 Receptor; D4 Receptor

Related Products

CatalogName
HY-116216-01PD 168368
HY-144649PD-1/PD-L1-IN-24
HY-132202-01PD-1/PD-L1-IN-10
HY-144442PD-1/PD-L1-IN-15
HY-129172APD-1/PD-L1-IN 5
HY-145770PD-1/PD-L1-IN-19
HY-179180PD-1/PD-L1-IN-59
HY-175702PD-1/PD-L1-IN-57
HY-144447PD-1/PD-L1-IN-17
HY-169190PD-1/PD-L1-IN-53

Alternative Products

CatalogName
GTR19212306-01PD 168568
MBS3614994-01PD 168568 dihydrochloride

Popular Products