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LP 12 (hydrochloride)

CAT: 0804-HY-103105Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-103105Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LP 12 hydrochloride (compound 21) is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively) [1][2].
CAS Number
1185136-22-4
UNSPSC
12352005
Hazard Statement
H319
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lp-12-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CCCC2=C1C=CC=C2)CCCCCN3CCN(C4=CC=CC=C4C5=CC=CC=C5)CC3.[H]Cl
Molecular Formula
C32H40ClN3O
Molecular Weight
518.13
Precautions
P264-P280-P305+P351+P338
References & Citations
[1]Marcello Leopoldo, et al. Structure-activity relationship study on N- (1,2,3,4-tetrahydronaphthalen-1-yl) -4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J Med Chem. 2007 Aug 23;50 (17) :4214-21. |[2]Sugiyama Y, et, al. Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice. J Reprod Dev. 2019 Dec 18;65 (6) :541-550.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor;5-HT7 Receptor; mLAG-3; MUC3; α-1 microglobulin

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