Rel-ACPT-I

CAT: 0804-HY-101387Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101387Size:1 mg
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Description
Rel-ACPT-I is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects[1][2][3][4][5].
CAS Number
[194918-76-8]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rel-acpt-i.html
Purity
99.0
Solubility
H2O : 2 mg/mL (ultrasonic; warming)
Smiles
OC([C@]1(C[C@H]([C@H](C1)C(O)=O)C(O)=O)N)=O
Molecular Formula
C8H11NO6
Molecular Weight
217.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Acher FC, et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40 (19) :3119-29. |[2]Domin H, et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94. |[3]Domin H, et al. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014 Jul;26 (1) :99-113.|[4]Chapman AG, et al. Anticonvulsant activity of a mGlu (4alpha) receptor selective agonist, (1S,3R,4S) -1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur J Pharmacol. 2001 Jul 20;424 (2) :107-13.|[5]Stachowicz K, et al. The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems. Neuropharmacology. 2009 Sep;57 (3) :227-34.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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