(rel) -Asperparaline A

• Description :

  (rel) -Asperparaline A ((rel) -Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel) -Asperparaline A is also a potent and selective antagonist of nAChR. (rel) -Asperparaline A exhibits paralytic activity in silk worms[1][2].

• Product Name Alternative :

  (rel) -Aspergillimide; (rel) -VM55598

• UNSPSC :

  12352005

• Target :

  NAChR

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/rel-asperparaline-a.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CN(C1=O)C(C[C@@]2(CC3=O)C(N3C)=O)(CN(CC[C@@H]4C)C14C5)[C@]5([H])C2(C)C.[Rotation(-)]

• Molecular Formula :

  C20H29N3O3

• Molecular Weight :

  359.46

• References & Citations :

  [1]Hayashi H, et, al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci Biotechnol Biochem. 2000 Jan;64 (1) :111-5.|[2]Hirata K, et, al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: the first report on the mode of action. PLoS One. 2011 Apr 1;6 (4) :e18354.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [195966-93-9]