CGP 20712 A

• Description:

  CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1].

• Product Name Alternative:

  CGP 20712 (mesylate)

• UNSPSC:

  12352005

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/cgp-20712-a.html

• Purity:

  99.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (N) C1=CC (OCCNCC (O) COC2=CC=C (C3=NC (C (F) (F) F) =CN3C) C=C2) =CC=C1O.CS (=O) (O) =O

• Molecular Formula:

  C24H29F3N4O8S

• Molecular Weight:

  590.57

• References & Citations:

  [1]Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130 (1-2) :137-9.|[2]Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116 (1) :1635-43.|[3]Grino M, et al. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. Endocrinology. 1992 Dec;131 (6) :2763-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  β adrenergic receptor

• CAS Number:

  105737-62-0