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6-Chloromelatonin

CAT: 0804-HY-100940Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100940Size:1 mg
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Description
6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [3H]-melatonin and 2-[125I]-iodomelatonin binding to MT1 receptors (pKi=8.9 and 9.1, respectively) . 6-Chloromelatonin compete for [3H]-melatonin binding to MT2 receptors (pKi=9.77) [1][2].
CAS Number
63762-74-3
UNSPSC
12352005
Hazard Statement
H301-H311-H315-H319-H331-H335-H360
Target
Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/6-chloromelatonin.html
Solubility
10 mM in DMSO
Smiles
CC(NCCC1=CNC2=C1C=C(OC)C(Cl)=C2)=O
Molecular Formula
C13H15ClN2O2
Molecular Weight
266.72
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501
References & Citations
[1]Browning C, et al. Pharmacological characterization of human recombinant melatonin mt (1) and MT (2) receptors. Br J Pharmacol. 2000;129 (5) :877-886.|[2]Clemens JA, et al. Inhibition of luteinizing hormone release and ovulation by 6-chloro- and 6-fluoromelatonin. Neuroendocrinology. 1980;30 (2) :83-87.|[3]Vacas MI, et al. Binding sites for [3H]-melatonin in human platelets. J Pineal Res. 1992;13 (2) :60-65.|[4]Lanoix D, et al. Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. Hum Reprod. 2006;21 (8) :1981-1989.|[5]Kennaway DJ, et al. A melatonin agonist and N-acetyl-N2-formyl-5-methoxykynurenamine accelerate the reentrainment of the melatonin rhythm following a phase advance of the light-dark cycle. Brain Res. 1989;495 (2) :349-354.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MT1; MT2

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