Aβ-IN-6

• Description:

  Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; NF-κB

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/aβ-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCN1C=C (N=N1) C/C (C (/C=C/C2=CC=C (C=C2) OC) =O) =C (\C=C\C3=CC=C (C=C3) OC) O

• Molecular Formula:

  C28H31N3O4

• Molecular Weight:

  473.56

• References & Citations:

  [1]Ersilia De Lorenzi, et al. Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold. Eur J Med Chem. 2023 Apr 5;252:115297.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3043752-01-5