Aβ-IN-6

• Description :

  Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research[1].

• CAS Number :

  [3043752-01-5]

• UNSPSC :

  12352005

• Target :

  Amyloid-β; Keap1-Nrf2

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; NF-κB

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/aβ-in-6.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCCN1C=C(N=N1)C/C(C(/C=C/C2=CC=C(C=C2)OC)=O)=C(\C=C\C3=CC=C(C=C3)OC)O

• Molecular Formula :

  C28H31N3O4

• Molecular Weight :

  473.56

• References & Citations :

  [1]Ersilia De Lorenzi, et al. Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold. Eur J Med Chem. 2023 Apr 5;252:115297.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported