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ML-9 (Free Base)

CAT: 0804-HY-100932ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100932ASize:1 Each
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Description
ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].
CAS Number
110448-31-2
UNSPSC
12352005
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml-9-free-base.html
Solubility
10 mM in DMSO
Smiles
O=S(N1CCNCCC1)(C2=C3C=CC=C(C3=CC=C2)Cl)=O
Molecular Formula
C15H17ClN2O2S
Molecular Weight
324.83
References & Citations
[1]Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23;486 (3) :325-33.|[2]Shaikh S, et al. The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.Toxicol In Vitro. 2018 Apr;48:121-127.|[3]Kondratskyi A1, et al.Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.Cell Death Dis. 2014 Apr 24;5:e1193.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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