RX 801077

CAT: 0804-HY-100904ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100904ASize:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI) [1][2].
CAS Number
[72583-92-7]
Product Name Alternative
2 BFI (free base)
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Imidazoline Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rx-801077.html
Solubility
10 mM in DMSO
Smiles
C1(C2=CC3=CC=CC=C3O2)=NCCN1
Molecular Formula
C11H10N2O
Molecular Weight
186.21
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272 (2) :681-8.|[2]Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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