RX 801077

• Description :

  RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI) [1][2].

• Product Name Alternative :

  2 BFI (free base)

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319

• Target :

  Imidazoline Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/rx-801077.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C1(C2=CC3=CC=CC=C3O2)=NCCN1

• Molecular Formula :

  C11H10N2O

• Molecular Weight :

  186.21

• Precautions :

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations :

  [1]Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272 (2) :681-8.|[2]Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [72583-92-7]