C-11

• UNSPSC Description:

  C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines[1].

• Target Antigen:

  ADC Cytotoxin; Microtubule/Tubulin

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/c-11.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N(C)[C@@H](C(C)C)C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=C(N)C=C2)C[C@H](C)C(O)=O)=O)=CS1)[C@H]([C@@H](C)CC)NC([C@@]3(C)CCCN3C)=O

• Molecular Weight:

  742.97

• References & Citations:

  [1]Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2007965-97-9