c-Met-IN-11

c-Met-IN-11

• CAS Number: 1446324-05-5
• UNSPSC Description: c-Met-IN-11 (compound 3) is a potent c-MET and VEGFR-2 inhibitor, with IC50 values of 41.4 and 71.1 nM, respectively[1].
• Target Antigen: c-Met/HGFR; VEGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/c-met-in-11.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC2=NC=CC(OC3=C(C=C(C=C3)NC4=C5C(C(C6=CC=C(C=C6)F)=CNC5=CC=N4)=O)F)=C2C=C1
• Molecular Weight: 522.50
• References & Citations: [1]Xu H, et al. Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2. Bioorg Med Chem. 2020 Jun 15;28(12):115555.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported