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PSB-12379 (disodium)

CAT: 0804-HY-100747ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100747ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PSB-12379 disodium, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human) [1][2].
UNSPSC
12352005
Target
CD73
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/psb-12379-disodium.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O[Na])CP(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)[C@H](O)[C@@H]1O)(O[Na])=O
Molecular Formula
C18H21N5Na2O9P2
Molecular Weight
559.31
References & Citations
[1]Bhattarai S, et al. α, β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58 (15) :6248-63.|[2]X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 -Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Sanjay Bhattarai. Adv. Therap. 2019, 2, 1900075.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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