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PSB-12379 (Standard)

CAT: 0804-HY-100747RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100747RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PSB-12379 (Standard) is the analytical standard of PSB-12379. This product is intended for research and analytical applications. PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human)[2].
CAS Number
1802226-78-3
Target
CD73; Reference Standards
Related Pathways
Immunology/Inflammation; Others
Field of Research
Cancer
Smiles
O=P(O)(O)CP(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)[C@H](O)[C@@H]1O)(O)=O
Molecular Formula
C18H23N5O9P2
Molecular Weight
515.35
References & Citations
[1]Bhattarai S, et al. α, β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58 (15) :6248-63.|[2]X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 -Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Sanjay Bhattarai. Adv. Therap. 2019, 2, 1900075.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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