Flecainide (acetate) (Standard)
CAT:
804-HY-17429R
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Flecainide (acetate) (Standard)
- CAS Number: 54143-56-5
- UNSPSC Description: Flecainide (acetate) (Standard) is the analytical standard of Flecainide (acetate). This product is intended for research and analytical applications. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
- Target Antigen: Sodium Channel
- Type: Reference Standards
- Related Pathways: Membrane Transporter/Ion Channel
- Field of Research: Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/flecainide-acetate-standard.html
- Smiles: O=C(NCC1NCCCC1)C2=CC(OCC(F)(F)F)=CC=C2OCC(F)(F)F.CC(O)=O
- Molecular Weight: 474.39
- References & Citations: [1]Yamashita T, Nakajima T, Hamada E,
 Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274(1):315-21.|[2]Desaphy JF, De Luca A, Didonna MP, Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554(Pt 2):321-34.|[3]Kohli V. Oral flecainide is effective in management of refractory tachycardia in infants. Indian Heart J. 2013 Mar-Apr;65(2):168-71.
- Shipping Conditions: Room temperature