Flecainide (acetate)

Flecainide (acetate)

• CAS Number: 54143-56-5
• UNSPSC Description: Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
• Target Antigen: Sodium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/flecainide-acetate.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 20 mg/mL (ultrasonic)
• Smiles: O=C(NCC1NCCCC1)C2=CC(OCC(F)(F)F)=CC=C2OCC(F)(F)F.CC(O)=O
• Molecular Weight: 474.39
• References & Citations: [1]Yamashita T, Nakajima T, Hamada E,
 Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274(1):315-21.|[2]Desaphy JF, De Luca A, Didonna MP, Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554(Pt 2):321-34.|[3]Kohli V. Oral flecainide is effective in management of refractory tachycardia in infants. Indian Heart J. 2013 Mar-Apr;65(2):168-71.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched