Flecainide-d4 (acetate)

• Description:

  Flecainide-d4 (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential[1][2].

• Product Name Alternative:

  R-818-d4

• UNSPSC:

  12352005

• Target:

  Sodium Channel

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cardiovascular Disease

• Purity:

  99.0

• Solubility:

  10 mM in DMSO|DMSO : 50mg/mL (ultrasonic) |H2O : 20mg/mL (ultrasonic)

• Smiles:

  CC(O)=O.O=C(C1=C(C=CC(OC([2H])([2H])C(F)(F)F)=C1)OC([2H])([2H])C(F)(F)F)NCC2CCCCN2

• Molecular Formula:

  C19H20D4F6N2O5

• Molecular Weight:

  478.42

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Yamashita T, Nakajima T, Hamada E, Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274 (1) :315-21.|[3]Desaphy JF, De Luca A, Didonna MP, Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554 (Pt 2) :321-34.|[4]Kohli V. Oral flecainide is effective in management of refractory tachycardia in infants. Indian Heart J. 2013 Mar-Apr;65 (2) :168-71.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1276197-21-7