Flecainide-d4 (acetate)

CAT: 0804-HY-17429SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17429SSize:1 mg
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Description
Flecainide-d4 (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential[1][2].
CAS Number
[1276197-21-7]
Product Name Alternative
R-818-d4
UNSPSC
12352005
Target
Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Purity
99.0
Solubility
10 mM in DMSO|DMSO : 50mg/mL (ultrasonic) |H2O : 20mg/mL (ultrasonic)
Smiles
CC(O)=O.O=C(C1=C(C=CC(OC([2H])([2H])C(F)(F)F)=C1)OC([2H])([2H])C(F)(F)F)NCC2CCCCN2
Molecular Formula
C19H20D4F6N2O5
Molecular Weight
478.42
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Yamashita T, Nakajima T, Hamada E, Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274 (1) :315-21.|[3]Desaphy JF, De Luca A, Didonna MP, Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554 (Pt 2) :321-34.|[4]Kohli V. Oral flecainide is effective in management of refractory tachycardia in infants. Indian Heart J. 2013 Mar-Apr;65 (2) :168-71.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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