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BAY 59-9435

CAT: 0804-HY-102056-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-102056-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM.
CAS Number
654059-21-9
UNSPSC
12352005
Target
Lipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/HSL-IN-2.html
Purity
99.9200
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C(C)C)=C(C)N(C(N2C[C@@H](C)CCC2)=O)O1
Molecular Formula
C14H22N2O3
Molecular Weight
266.34
References & Citations
[1]Ebdrup S, et al. Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase. J Med Chem. 2004 Jan 15;47 (2) :400-10.|[2]Elizabeth A Rondini, et al. Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown AdipocytesJ Pharmacol Exp Ther. 2017 Dec;363 (3) :367-376.|[3]Wenliang Zhang, et al. Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity. J Biol Chem. 2014 Nov 14;289 (46) :32178-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-carbonyl)isoxazol-5(2H)-one
CAS Number654059-21-9
PubChem CID10038557
IUPAC Name3-methyl-2-[(3S)-3-methylpiperidine-1-carbonyl]-4-propan-2-yl-1,2-oxazol-5-one
Molecular FormulaC14H22N2O3
Molecular Weight266.34
XLogP2.5
Topological Polar Surface Area49.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity428
SMILES
C[C@H]1CCCN(C1)C(=O)N2C(=C(C(=O)O2)C(C)C)C
InChI
InChI=1S/C14H22N2O3/c1-9(2)12-11(4)16(19-13(12)17)14(18)15-7-5-6-10(3)8-15/h9-10H,5-8H2,1-4H3/t10-/m0/s1
InChIKey
XWESKOHENXWEAX-JTQLQIEISA-N
Chemical Structure
2D Structure
2D structure of (S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-carbonyl)isoxazol-5(2H)-one
CAS: 654059-21-9
CID: 10038557
Formula: C14H22N2O3
MW: 266.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight266.34
XLogP32.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass266.16304257
Monoisotopic Mass266.16304257
Topological Polar Surface Area49.9 Ų
Heavy Atom Count19
Formal Charge0
Complexity428
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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