APP-018

• Description :

  APP-018 (D-4F) is 18 D-amino acids peptide that mimics apolipoprotein A-I (apoA-I) . APP-018 improves the anti-inflammatory activity of high-density lipoprotein (HDL) . APP-018 can be used in researches of cardiovascular diseases[1].

• Product Name Alternative :

  D-4F

• UNSPSC :

  12352209

• Target :

  Apolipoprotein

• Type :

  Peptides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/app-018.html

• Purity :

  99.80

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  C([C@H](C(N[C@H](CC1=CC=CC=C1)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC2=CC=C(O)C=C2)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC3=CC=CC=C3)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC4=CC=CC=C4)C(N)=O)=O)C)=O)CCC(O)=O)=O)CCCCN)=O)=O)CCCCN)=O)CCC(O)=O)=O)C)=O)C(C)C)=O)CCCCN)=O)CC(O)=O)=O)=O)CC5=CC=CC=C5)=O)C)=O)CCCCN)=O)=O)NC([C@@H](CC(O)=O)NC(C)=O)=O)C=6C=7C(NC6)=CC=CC7

• Molecular Formula :

  C114H156N24O28

• Molecular Weight :

  2310.60

• References & Citations :

  [1]Bloedon LT, et al., Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients. J Lipid Res. 2008 Jun;49 (6) :1344-52.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [452782-06-8]