APP-018

• Description:

  APP-018 (D-4F) is 18 D-amino acids peptide that mimics apolipoprotein A-I (apoA-I) . APP-018 improves the anti-inflammatory activity of high-density lipoprotein (HDL) . APP-018 can be used in researches of cardiovascular diseases[1].

• Product Name Alternative:

  D-4F

• UNSPSC:

  12352209

• Target:

  Apolipoprotein

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/app-018.html

• Purity:

  99.80

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  C([C@H](C(N[C@H](CC1=CC=CC=C1)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC2=CC=C(O)C=C2)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC3=CC=CC=C3)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC4=CC=CC=C4)C(N)=O)=O)C)=O)CCC(O)=O)=O)CCCCN)=O)=O)CCCCN)=O)CCC(O)=O)=O)C)=O)C(C)C)=O)CCCCN)=O)CC(O)=O)=O)=O)CC5=CC=CC=C5)=O)C)=O)CCCCN)=O)=O)NC([C@@H](CC(O)=O)NC(C)=O)=O)C=6C=7C(NC6)=CC=CC7

• Molecular Formula:

  C114H156N24O28

• Molecular Weight:

  2310.60

• References & Citations:

  [1]Bloedon LT, et al., Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients. J Lipid Res. 2008 Jun;49 (6) :1344-52.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [452782-06-8]