RM-018

CAT: 0931-T40269-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T40269-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2641993-55-5

Target

Others, Kras, Ras

Related Pathways

Others, GPCR/G Protein, MAPK

Bioactivity

RM-018 is a powerful tricomplex inhibitor that specifically targets the active state of KRAS G12C. It exhibits unique functional characteristics and possesses the ability to bind and inhibit both KRAS G12C and KRAS G12C/Y96D, potentially overcoming resistance.

Smiles

CCn1c(c2CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C(=O)[C@H](Cc3cccc(c3)-c3ccc1c2c3)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C1)C(=O)C#CCN1CCOCC1)-c1cccnc1[C@H](C)OC

Molecular Formula

C56H72N8O8

Molecular Weight

985.24

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

(3S)-N-[(2S)-1-[[(8S,14S)-22-ethyl-21-[2-[(1S)-1-methoxyethyl]-3-pyridinyl]-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.12,6.110,14.023,27]nonacosa-1(26),2,4,6(29),20,23(27),24-heptaen-8-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methyl-1-(4-morpholin-4-ylbut-2-ynoyl)pyrrolidine-3-carboxamide

CAS Number	2641993-55-5
PubChem CID	161776064
IUPAC Name	(3S)-N-[(2S)-1-[[(8S,14S)-22-ethyl-21-[2-[(1S)-1-methoxyethyl]-3-pyridinyl]-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.12,6.110,14.023,27]nonacosa-1(26),2,4,6(29),20,23(27),24-heptaen-8-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methyl-1-(4-morpholin-4-ylbut-2-ynoyl)pyrrolidine-3-carboxamide
Molecular Formula	C56H72N8O8
Molecular Weight	985.2
XLogP	5.8
Topological Polar Surface Area	168
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	10
Heavy Atom Count	72
Formal Charge	0
Complexity	1970

SMILES

CCN1C2=C3C=C(C=C2)C4=CC=CC(=C4)C[C@@H](C(=O)N5CCC[C@H](N5)C(=O)OCC(CC3=C1C6=C(N=CC=C6)[C@H](C)OC)(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]7CCN(C7)C(=O)C#CCN8CCOCC8

InChI

InChI=1S/C56H72N8O8/c1-9-63-47-20-19-40-32-43(47)44(51(63)42-16-11-22-57-49(42)37(4)70-8)33-56(5,6)35-72-55(69)45-17-12-24-64(59-45)54(68)46(31-38-14-10-15-39(40)30-38)58-52(66)50(36(2)3)60(7)53(67)41-21-25-62(34-41)48(65)18-13-23-61-26-28-71-29-27-61/h10-11,14-16,19-20,22,30,32,36-37,41,45-46,50,59H,9,12,17,21,23-29,31,33-35H2,1-8H3,(H,58,66)/t37-,41-,45-,46-,50-/m0/s1

InChIKey

KXMPBNBAZLJBDS-GUZCBZAASA-N

Chemical Structure

2D Structure

CAS: 2641993-55-5

CID: 161776064

Formula: C56H72N8O8

MW: 985.2

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	985.2
XLogP3	5.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	10
Exact Mass	984.54731128
Monoisotopic Mass	984.54731128
Topological Polar Surface Area	168 Å²
Heavy Atom Count	72
Formal Charge	0
Complexity	1970
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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TP2982-01	APP-018
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T26102	RM 49
T202386-01	RM-5038
T210223-01	LLW-018
T89897-01	RGT-018
T73464-01	TYA-018
TCL-00106-01	RM 137-15
T24929-01	V-06-018

Alternative Products

Catalog	Name
HY-141477-01	RM-018
444039-01	CBL-018
MBS3841494-01	NS-018
TRC-E440195-500MG	EG 018
TRC-P283650-5MG	JWH-018
GTR19262778-01	LLW-018
M36531-01	TYA-018
E4697-1g	RGT-018
HY-107142	RM-5038
448090-01	EG2201 RM

RM-018

Chemical Information

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