PF-04691502

• Description :

  PF-04691502 is a potent and selective inhibitor of PI3K and mTOR. PF-04691502 binds to human PI3Kα, β, δ, γ and mTOR with Kis of 1.8, 2.1, 1.6, 1.9 and 16 nM, respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; mTOR; PI3K

• Type :

  Reference compound

• Related Pathways :

  Autophagy; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pf-04691502.html

• Purity :

  99.91

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OCCO[C@@H]1CC[C@@H](N2C(N=C(N)N=C3C)=C3C=C(C4=CC=C(OC)N=C4)C2=O)CC1

• Molecular Formula :

  C22H27N5O4

• Molecular Weight :

  425.48

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Yuan J, et al. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol Cancer Ther. 2011 Nov;10 (11) :2189-99.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  MTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

• CAS Number :

  [1013101-36-4]